The 33-room Observatory Hotel will open in the historic complex of buildings on May 7.
Arts Centre director Philip Aldridge said the hotel, which takes up the historic biology and physics buildings on Hereford St, was unique for its location and design.
The public spaces feature art for sale curated by The Central Art Gallery, with art in the rooms curated by The Creators Room.
In the hotel’s ornate drawing room, described as the “heart of the hotel” by Bretherton, there are paintings by Dick Frizzel and Leigh Martin on display and available for purchase.